Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines
MG Masucic, NJ Stam, S Torsteinsdottir, JJ Neefjes… - Cellular …, 1989 - Elsevier
We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are
resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs (10, 11). Here we show
that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The
HLA-A11 negative phenotype is due to a regulatory phenomenon, rather than a structural
defect, as proven by the ability to rescue expression of HLA-A11 in in vitro Epstein-Barr virus
(EBV)-converted sublines of EBV negative BLs.
resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs (10, 11). Here we show
that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The
HLA-A11 negative phenotype is due to a regulatory phenomenon, rather than a structural
defect, as proven by the ability to rescue expression of HLA-A11 in in vitro Epstein-Barr virus
(EBV)-converted sublines of EBV negative BLs.