Highlights•The strain-specificity of most neutralizing antibodies against influenza poses
difficulties in inducing broadly protective immunity.•Influenza-specific ADCC assists in the
control of influenza in vitro and in animal models.•Influenza-specific ADCC in humans can
react broadly against diverse influenza strains.•Influenza-specific ADCC is associated with
resolution of influenza infection of humans in early studies.•Further study of ADCC is a
promising avenue of research towards improving protective immunity to influenza.Antibodies …