Genetic aspects of hypothalamic and pituitary gland development

MJ McCabe, MT Dattani - Handbook of clinical neurology, 2014 - Elsevier
Hypothalamo-pituitary development during embryogenesis is a highly complex process
involving the interaction of a network of spatiotemporally regulated signaling molecules and
transcription factors. Mutations in any of the genes encoding these components can lead to
congenital hypopituitarism, which is often associated with a wide spectrum of defects
affecting craniofacial/midline development. In turn, these defects can be incompatible with
life, or lead to disorders encompassing holoprosencephaly (HPE) and cleft palate, and septo …