Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development
SR Smith, MC Ghosh, H Ollivierre-Wilson… - Blood Cells, Molecules …, 2006 - Elsevier
Iron regulatory proteins 1 and 2 (IRPs) are homologous mammalian cytosolic proteins that
sense intracellular iron levels and post-transcriptionally regulate expression of ferritin,
transferrin receptor, and other iron metabolism proteins. Adult mice with homozygous
targeted deletion of IRP2 develop microcytic anemia, elevated red cell protoporphyrin IX
levels, high serum ferritin, and adult-onset neurodegeneration. Mice with homozygous
deletion of IRP1 develop no overt abnormalities, but mice that lack both copies of IRP2 and …
sense intracellular iron levels and post-transcriptionally regulate expression of ferritin,
transferrin receptor, and other iron metabolism proteins. Adult mice with homozygous
targeted deletion of IRP2 develop microcytic anemia, elevated red cell protoporphyrin IX
levels, high serum ferritin, and adult-onset neurodegeneration. Mice with homozygous
deletion of IRP1 develop no overt abnormalities, but mice that lack both copies of IRP2 and …