[HTML][HTML] Passive administration of purified secretory IgA from human colostrum induces protection against Mycobacterium tuberculosis in a murine model of …
N Alvarez, O Otero, F Camacho, R Borrero, Y Tirado… - BMC immunology, 2013 - Springer
BMC immunology, 2013•Springer
Background Immunoglobulin A is the most abundant isotype in secretions from mucosal
surfaces of the gastrointestinal, respiratory and genitourinary tracts and in external
secretions such as colostrum, breast milk, tears and saliva. The high concentration of human
secretory IgA (hsIgA) in human colostrum strongly suggests that it should play an important
role in the passive immune protection against gastrointestinal and respiratory infections.
Materials and methods Human secretory IgA was purified from colostrum. The reactivity of …
surfaces of the gastrointestinal, respiratory and genitourinary tracts and in external
secretions such as colostrum, breast milk, tears and saliva. The high concentration of human
secretory IgA (hsIgA) in human colostrum strongly suggests that it should play an important
role in the passive immune protection against gastrointestinal and respiratory infections.
Materials and methods Human secretory IgA was purified from colostrum. The reactivity of …
Background
Immunoglobulin A is the most abundant isotype in secretions from mucosal surfaces of the gastrointestinal, respiratory and genitourinary tracts and in external secretions such as colostrum, breast milk, tears and saliva. The high concentration of human secretory IgA (hsIgA) in human colostrum strongly suggests that it should play an important role in the passive immune protection against gastrointestinal and respiratory infections.
Materials and methods
Human secretory IgA was purified from colostrum. The reactivity of hsIgA against mycobacterial antigens and its protective capacity against mycobacterial infection was evaluated.
Results
The passive administration of hsIgA reduces the pneumonic area before challenge with M. tuberculosis. The intratracheal administration of M. tuberculosis preincubated with hsIgA to mice greatly reduced the bacterial load in the lungs and diminished lung tissue injury.
Conclusions
HsIgA purified from colostrum protects against M. tuberculosis infection in an experimental mouse model.
Springer