[HTML][HTML] Systemic vaccination induces clonally diverse SIV-specific CD8+ T-cell populations in systemic and mucosal compartments
P Sircar, KL Furr, NL Letvin - Mucosal immunology, 2013 - Elsevier
An HIV-1 vaccine must elicit a clonally diverse virus-specific CD8+ T-cell response to
contain mutant virus forms, and these responses must be present in mucosal tissues, which
are the site of early HIV-1 replication. We show that systemic delivery of prototype vaccine
vectors in rhesus monkeys induced SIV (simian immunodeficiency virus)-specific CD8+ T-
cell responses in systemic and mucosal compartments with comparable clonal
compositions. Although clonal sharing was maintained between the peripheral blood and …
contain mutant virus forms, and these responses must be present in mucosal tissues, which
are the site of early HIV-1 replication. We show that systemic delivery of prototype vaccine
vectors in rhesus monkeys induced SIV (simian immunodeficiency virus)-specific CD8+ T-
cell responses in systemic and mucosal compartments with comparable clonal
compositions. Although clonal sharing was maintained between the peripheral blood and …