Current practice in the diagnosis of bile acid diarrhea

P Vijayvargiya, M Camilleri - Gastroenterology, 2019 - gastrojournal.org
Bile acids (BAs) are synthesized from the liver to aid in fat and fat-soluble vitamin
solubilization and absorption. Approximately 95% of the unbound BAs are reabsorbed via
the ileal BA transporter and transported through the portal circulation to the liver for recycling
(Figure 1). 1, 2 BA diarrhea (BAD) is a condition characterized by excess BAs within the
colon, resulting in increased colonic motility and secretion. Patients typically present with
chronic diarrhea, urgency, and abdominal cramping. 2 There have been a number of novel …