Characterizing factors associated with differences in FGF19 blood levels and synthesis in patients with primary bile acid diarrhea
IM Johnston, JD Nolan, SS Pattni… - Official journal of the …, 2016 - journals.lww.com
IM Johnston, JD Nolan, SS Pattni, RN Appleby, JH Zhang, SL Kennie, GK Madhan…
Official journal of the American College of Gastroenterology| ACG, 2016•journals.lww.comOBJECTIVES: Chronic diarrhea caused by primary bile acid diarrhea (PBAD) is a common
condition. We have previously shown PBAD is associated with low fasting serum levels of
the ileal hormone, fibroblast growth factor 19 (FGF19). FGF19 is a negative regulator of
hepatic bile acid synthesis and is stimulated by farnesoid X receptor agonists, which
produce symptomatic improvement in PBAD. We aimed to assess possible causes for low
serum FGF19 in patients with PBAD. METHODS: Patients with PBAD, defined by reduced 75 …
condition. We have previously shown PBAD is associated with low fasting serum levels of
the ileal hormone, fibroblast growth factor 19 (FGF19). FGF19 is a negative regulator of
hepatic bile acid synthesis and is stimulated by farnesoid X receptor agonists, which
produce symptomatic improvement in PBAD. We aimed to assess possible causes for low
serum FGF19 in patients with PBAD. METHODS: Patients with PBAD, defined by reduced 75 …
Abstract
OBJECTIVES:
Chronic diarrhea caused by primary bile acid diarrhea (PBAD) is a common condition. We have previously shown PBAD is associated with low fasting serum levels of the ileal hormone, fibroblast growth factor 19 (FGF19). FGF19 is a negative regulator of hepatic bile acid synthesis and is stimulated by farnesoid X receptor agonists, which produce symptomatic improvement in PBAD. We aimed to assess possible causes for low serum FGF19 in patients with PBAD.
METHODS:
Patients with PBAD, defined by reduced 75 Se-labelled homocholic acid taurine (SeHCAT) retention, and idiopathic diarrhea controls had measurements of fasting lipids and fasting/post-prandial FGF19 serum profiles. Specific functional variants in candidate genes were investigated in exploratory studies. In further groups, basal and bile acid-stimulated transcript expression was determined in ileal biopsies and explant cultures by quantitative PCR.
RESULTS:
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