Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption
A Bajor, A Kilander, A Fae, C Gälman… - European journal of …, 2006 - journals.lww.com
Objectives Primarily, to determine whether there is a reduced active bile acid uptake in the
terminal ileum in patients with bile acid malabsorption. Secondarily, to study the linkage
between bile acid malabsorption and hepatic bile acid synthesis. Methods Ileal biopsies
were taken from patients with diarrhoea and from controls with normal bowel habits.
Maximal active bile acid uptake was assessed in ileal biopsies using a previously validated
technique based on uptake of 14 C-labelled taurocholate. To monitor the hepatic synthesis …
terminal ileum in patients with bile acid malabsorption. Secondarily, to study the linkage
between bile acid malabsorption and hepatic bile acid synthesis. Methods Ileal biopsies
were taken from patients with diarrhoea and from controls with normal bowel habits.
Maximal active bile acid uptake was assessed in ileal biopsies using a previously validated
technique based on uptake of 14 C-labelled taurocholate. To monitor the hepatic synthesis …