[HTML][HTML] Cardiac myocyte p38α kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart
BA Rose, T Yokota, V Chintalgattu, S Ren… - Journal of Biological …, 2017 - ASBMB
Stress-induced p38 mitogen-activated protein kinase (MAPK) activity is implicated in
pathological remodeling in the heart. For example, constitutive p38 MAPK activation in
cardiomyocytes induces pathological features, including myocyte hypertrophy, apoptosis,
contractile dysfunction, and fetal gene expression. However, the physiological function of
cardiomyocyte p38 MAPK activity in beneficial compensatory vascular remodeling is
unclear. This report investigated the functional role and the underlying mechanisms of …
pathological remodeling in the heart. For example, constitutive p38 MAPK activation in
cardiomyocytes induces pathological features, including myocyte hypertrophy, apoptosis,
contractile dysfunction, and fetal gene expression. However, the physiological function of
cardiomyocyte p38 MAPK activity in beneficial compensatory vascular remodeling is
unclear. This report investigated the functional role and the underlying mechanisms of …