PVDOMICS: a multi-center study to improve understanding of pulmonary vascular disease through phenomics

AR Hemnes, GJ Beck, JH Newman, A Abidov… - Circulation …, 2017 - Am Heart Assoc
AR Hemnes, GJ Beck, JH Newman, A Abidov, MA Aldred, J Barnard, E Berman Rosenzweig
Circulation research, 2017Am Heart Assoc
Lung and Blood institute (NHLBI) launched an initiative, PVDOMICS (Redefining Pulmonary
Hypertension through Pulmonary Vascular Disease Phenomics) that aims to augment the
current pulmonary hypertension (PH) classification based on shared biological features.
PVDOMICS will enroll 1500 participants with PH and disease and healthy comparators.
Enrollees will undergo deep clinical phenotyping, and blood will be acquired for
comprehensive omic analyses that will focus on discovery of molecular-based subtypes of …
Lung and Blood institute (NHLBI) launched an initiative, PVDOMICS (Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics) that aims to augment the current pulmonary hypertension (PH) classification based on shared biological features. PVDOMICS will enroll 1500 participants with PH and disease and healthy comparators. Enrollees will undergo deep clinical phenotyping, and blood will be acquired for comprehensive omic analyses that will focus on discovery of molecular-based subtypes of pulmonary vascular disease (PVD) through application of high dimensional model-based clustering methods. In addition to an updated, molecular classification of PVD, the phenomic data generated will be a rich resource to the broad community of heart and lung disease investigators.
Am Heart Assoc