CD8+ T cells have been described as being naive or one of 4 antigen (Ag)-experienced
subtypes representing a continuum of differentiation and maturation: T memory stem cell,
central memory T cell, effector memory T cell, and terminally differentiated effector T cells. In
mice, adoptive cell transfer of less-differentiated naive T cells, T memory stem cell, and
central memory T cell subsets have consistently demonstrated superior in vivo expansion,
persistence, and antitumor capacities relative to the more differentiated effector memory T …