Increased oxidative metabolism is associated with erythroid precursor expansion in β0-thalassaemia/Hb E disease
A Leecharoenkiat, T Wannatung… - Blood Cells, Molecules …, 2011 - Elsevier
Erythropoiesis in β0-thalassaemia/Hb E patients, the most common variant form of β-
thalassaemia in Southeast Asia, is characterized by accelerated differentiation and over-
expansion of erythroid precursor cells. The mechanism driving this accelerated expansion
and differentiation remain unknown. To address this issue a proteomic analysis was
undertaken to firstly identify proteins differentially expressed during erythroblast
differentiation and a second analysis was undertaken to identify proteins differentially …
thalassaemia in Southeast Asia, is characterized by accelerated differentiation and over-
expansion of erythroid precursor cells. The mechanism driving this accelerated expansion
and differentiation remain unknown. To address this issue a proteomic analysis was
undertaken to firstly identify proteins differentially expressed during erythroblast
differentiation and a second analysis was undertaken to identify proteins differentially …