Induction of CXCR3-and CCR5-associated chemokines during acute hepatitis C virus infection
M Zeremski, G Hooker, MA Shu, E Winkelstein… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: Characterization of inflammatory mediators, such as chemokines,
during acute hepatitis C virus (HCV) infection might shed some light on viral clearance
mechanisms. METHODS: Plasma levels of CXCR3 (CXCL9–11)-and CCR5 (CCL3–4)-
associated chemokines, ALT, and HCV RNA were measured in nine injection drug users
(median 26 samples/patient) before and during 10 acute (eight primary and two secondary)
HCV infections. Using functional data analysis, we estimated smooth long-term trends in …
during acute hepatitis C virus (HCV) infection might shed some light on viral clearance
mechanisms. METHODS: Plasma levels of CXCR3 (CXCL9–11)-and CCR5 (CCL3–4)-
associated chemokines, ALT, and HCV RNA were measured in nine injection drug users
(median 26 samples/patient) before and during 10 acute (eight primary and two secondary)
HCV infections. Using functional data analysis, we estimated smooth long-term trends in …