[HTML][HTML] Protective and dysregulated T cell immunity in RSV infection

PJ Openshaw, C Chiu - Current opinion in virology, 2013 - Elsevier
Highlights•T cell responses play an important role in clearance of RSV, and probably in
protective immunity.•T cells are also responsible for immune-mediated tissue damage in
RSV infection and in vaccine-enhanced disease.•RSV possesses multiple immune evasion
strategies that inhibit T cell function via soluble factors and dendritic cells.•Dysregulated
immune responses to RSV infection may partly account for severe disease.•Therapeutic
strategies aimed at boosting regulatory T cell responses might be beneficial.Respiratory …