[HTML][HTML] Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia

JM Lanis, EE Alexeev, VF Curtis, DA Kitzenberg… - Mucosal …, 2017 - Elsevier
IL-10 is a potent anti-inflammatory cytokine that inhibits the production of proinflammatory
mediators. Signaling by IL-10 occurs through the IL-10 receptor (IL-10R), which is expressed
in numerous cell types, including intestinal epithelial cells (IECs), where it is associated with
development and maintenance of barrier function. Guided by an unbiased metabolomics
screen, we identified tryptophan (Trp) metabolism as a major modifying pathway in
interferon-γ (IFNγ)-dominant murine colitis. In parallel, we demonstrated that IFNγ induction …