Using noise signature to optimize spike-sorting and to assess neuronal classification quality

C Pouzat, O Mazor, G Laurent - Journal of neuroscience methods, 2002 - Elsevier
Journal of neuroscience methods, 2002Elsevier
We have developed a simple and expandable procedure for classification and validation of
extracellular data based on a probabilistic model of data generation. This approach relies on
an empirical characterization of the recording noise. We first use this noise characterization
to optimize the clustering of recorded events into putative neurons. As a second step, we use
the noise model again to assess the quality of each cluster by comparing the within-cluster
variability to that of the noise. This second step can be performed independently of the …
We have developed a simple and expandable procedure for classification and validation of extracellular data based on a probabilistic model of data generation. This approach relies on an empirical characterization of the recording noise. We first use this noise characterization to optimize the clustering of recorded events into putative neurons. As a second step, we use the noise model again to assess the quality of each cluster by comparing the within-cluster variability to that of the noise. This second step can be performed independently of the clustering algorithm used, and it provides the user with quantitative as well as visual tests of the quality of the classification.
Elsevier