Influence of bone marrow microenvironment on leukemic stem cells: breaking up an intimate relationship

P Agarwal, R Bhatia - Advances in Cancer Research, 2015 - Elsevier
The bone marrow microenvironment (BMM) plays a critical role in hematopoietic stem cells
(HSCs) maintenance and regulation. There is increasing interest in the role of the BMM in
promoting leukemia stem cell (LSC) maintenance, resistance to conventional chemotherapy
and targeted therapies, and ultimately disease relapse. Recent studies have enhanced our
understanding of how the BMM regulates quiescence, self-renewal, and differentiation of
LSC. In this comprehensive review, we discuss recent advances in our understanding of the …