Cancer stem cells (CSCs) represent a small subpopulation of self-renewing oncogenic cells.
As in many other stem cells, metabolic reprogramming has been implicated to be a key
characteristic of CSCs. However, little is known about how the metabolic features of cancer
cells are controlled to orchestrate their CSC-like properties. We recently demonstrated that
hyaluronan (HA) overproduction allowed plastic cancer cells to revert to stem cell states.
Here, we adopted stable isotope-assisted tracing and mass spectrometry profiling to …