Levels of extra domain A containing fibronectin in human atherosclerotic plaques are associated with a stable plaque phenotype
JK van Keulen, DP de Kleijn, MMO Nijhuis, E Busser… - Atherosclerosis, 2007 - Elsevier
BACKGROUND: Extra domain A (EDA), splice-variant of fibronectin, is a Toll-like receptor 4
(Tlr4) ligand. Recently, EDA has been demonstrated to enhance atherogenesis in mice but
human data on the role of EDA in atherosclerotic disease are lacking. We hypothesized that
EDA is associated with unstable plaque phenotypes and that plasma EDA could serve as
biomarker for atherosclerosis. METHODS: EDA levels were assessed in carotid
endarterectomy specimen (206 patients) and related with plaque phenotype. In a second …
(Tlr4) ligand. Recently, EDA has been demonstrated to enhance atherogenesis in mice but
human data on the role of EDA in atherosclerotic disease are lacking. We hypothesized that
EDA is associated with unstable plaque phenotypes and that plasma EDA could serve as
biomarker for atherosclerosis. METHODS: EDA levels were assessed in carotid
endarterectomy specimen (206 patients) and related with plaque phenotype. In a second …