[HTML][HTML] Hypoxia potentiates the radiation-sensitizing effect of olaparib in human non-small cell lung cancer xenografts by contextual synthetic lethality
Y Jiang, T Verbiest, AM Devery, SM Bokobza… - International Journal of …, 2016 - Elsevier
Purpose Poly (ADP-ribose) polymerase (PARP) inhibitors potentiate radiation therapy in
preclinical models of human non-small cell lung cancer (NSCLC) and other types of cancer.
However, the mechanisms underlying radiosensitization in vivo are incompletely
understood. Herein, we investigated the impact of hypoxia on radiosensitization by the
PARP inhibitor olaparib in human NSCLC xenograft models. Methods and Materials NSCLC
Calu-6 and Calu-3 cells were irradiated in the presence of olaparib or vehicle under …
preclinical models of human non-small cell lung cancer (NSCLC) and other types of cancer.
However, the mechanisms underlying radiosensitization in vivo are incompletely
understood. Herein, we investigated the impact of hypoxia on radiosensitization by the
PARP inhibitor olaparib in human NSCLC xenograft models. Methods and Materials NSCLC
Calu-6 and Calu-3 cells were irradiated in the presence of olaparib or vehicle under …