Purpose Poly (ADP-ribose) polymerase (PARP) inhibitors have been shown to enhance the
radiosensitivity of cancer cells in vitro in a replication-dependent manner. Their in vivo
radiosensitizing effects have also been demonstrated in preclinical tumor models. However,
whether PARP inhibition can enhance the response to radiation therapy in normal tissues
has been largely neglected. We hypothesized that PARP inhibition might also potentiate the
response of replicating normal tissues to radiation therapy. In this study, we examined the …