[HTML][HTML] PGC-1β in the regulation of hepatic glucose and energy metabolism

J Lin, PT Tarr, R Yang, J Rhee, P Puigserver… - Journal of Biological …, 2003 - ASBMB
Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a transcriptional
coactivator that regulates multiple aspects of cellular energy metabolism, including
mitochondrial biogenesis, hepatic gluconeogenesis, and β-oxidation of fatty acids. PGC-1α
mRNA levels are increased in both type-1 and type-2 diabetes and may contribute to
elevated hepatic glucose production in diabetic states. We have recently described PGC-1β,
a novel transcriptional coactivator that is a homolog of PGC-1α. Although PGC-1β shares …