Fatal toxic effects associated with immune checkpoint inhibitors: a systematic review and meta-analysis
Importance Immune checkpoint inhibitors (ICIs) are now a mainstay of cancer treatment.
Although rare, fulminant and fatal toxic effects may complicate these otherwise
transformative therapies; characterizing these events requires integration of global data.
Objective To determine the spectrum, timing, and clinical features of fatal ICI-associated
toxic effects. Design, Setting, and Participants We retrospectively queried a World Health
Organization (WHO) pharmacovigilance database (Vigilyze) comprising more than 16 000 …
Although rare, fulminant and fatal toxic effects may complicate these otherwise
transformative therapies; characterizing these events requires integration of global data.
Objective To determine the spectrum, timing, and clinical features of fatal ICI-associated
toxic effects. Design, Setting, and Participants We retrospectively queried a World Health
Organization (WHO) pharmacovigilance database (Vigilyze) comprising more than 16 000 …