Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis
Y Wang, DH Wiesnoski, BA Helmink… - Nature medicine, 2018 - nature.com
Y Wang, DH Wiesnoski, BA Helmink, V Gopalakrishnan, K Choi, HL DuPont, ZD Jiang…
Nature medicine, 2018•nature.comWe report the first case series of immune checkpoint inhibitors (ICI)-associated colitis
successfully treated with fecal microbiota transplantation, with reconstitution of the gut
microbiome and a relative increase in the proportion of regulatory T-cells within the colonic
mucosa. These preliminary data provide evidence that modulation of the gut microbiome
may abrogate ICI-associated colitis.
successfully treated with fecal microbiota transplantation, with reconstitution of the gut
microbiome and a relative increase in the proportion of regulatory T-cells within the colonic
mucosa. These preliminary data provide evidence that modulation of the gut microbiome
may abrogate ICI-associated colitis.
Abstract
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.
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