Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal
tubule. This process involves two interacting receptors, megalin and cubilin, which form a
complex with amnionless. Whether these proteins function in parallel or as part of an
integrated system is not well understood. Here, we report the renal effects of genetic ablation
of cubilin, with or without concomitant ablation of megalin, using a conditional Cre-loxP
system. We observed that proximal tubule cells did not localize amnionless to the plasma …