Molecular views of recombination proteins and their control

SC West - Nature reviews Molecular cell biology, 2003 - nature.com
Nature reviews Molecular cell biology, 2003nature.com
The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome
stability and cell survival. Homologous recombination provides an efficient and faithful
pathway of repair, especially in replicating cells, in which it plays a major role in tumour
avoidance. Many of the enzymes that are involved in recombination have been isolated, and
the details of this pathway are now being unravelled at the molecular level.
Abstract
The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome stability and cell survival. Homologous recombination provides an efficient and faithful pathway of repair, especially in replicating cells, in which it plays a major role in tumour avoidance. Many of the enzymes that are involved in recombination have been isolated, and the details of this pathway are now being unravelled at the molecular level.
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