Imagestream detection and characterisation of circulating tumour cells–A liquid biopsy for hepatocellular carcinoma?
LF Ogle, JG Orr, CE Willoughby, C Hutton… - Journal of …, 2016 - Elsevier
Background & Aims The lack of progress in developing and delivering new therapies for
hepatocellular carcinoma (HCC) is in part attributed to the risk related avoidance of tumour
biopsy at diagnosis. Circulating tumour cells (CTCs) are a potential source of tumour tissue
that could aid biological or biomarker research, treatment stratification and monitoring.
Methods An imaging flow cytometry method, using immunofluorescence of cytokeratin,
EpCAM, AFP, glypican-3 and DNA-PK together with analysis of size, morphology and DNA …
hepatocellular carcinoma (HCC) is in part attributed to the risk related avoidance of tumour
biopsy at diagnosis. Circulating tumour cells (CTCs) are a potential source of tumour tissue
that could aid biological or biomarker research, treatment stratification and monitoring.
Methods An imaging flow cytometry method, using immunofluorescence of cytokeratin,
EpCAM, AFP, glypican-3 and DNA-PK together with analysis of size, morphology and DNA …