Nasal IL-5 levels determine the response to anti–IL-5 treatment in patients with nasal polyps
P Gevaert, D Lang-Loidolt, A Lackner… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: Chronic rhinosinusitis with nasal polyps is characterized by an eosinophilic
inflammation and high IL-5 levels. OBJECTIVES: Antagonizing the effect of IL-5 is a potential
new treatment strategy in patients with nasal polyps. METHODS: In a double-blind, placebo-
controlled, randomized, 2-center safety and pharmacokinetic study, 24 subjects with bilateral
nasal polyps were randomized to receive a single intravenous infusion of reslizumab, a
humanized anti-human IL-5 mAb, at 3 mg/kg or 1 mg/kg or placebo. We evaluated the safety …
inflammation and high IL-5 levels. OBJECTIVES: Antagonizing the effect of IL-5 is a potential
new treatment strategy in patients with nasal polyps. METHODS: In a double-blind, placebo-
controlled, randomized, 2-center safety and pharmacokinetic study, 24 subjects with bilateral
nasal polyps were randomized to receive a single intravenous infusion of reslizumab, a
humanized anti-human IL-5 mAb, at 3 mg/kg or 1 mg/kg or placebo. We evaluated the safety …