Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
N Rabinovitch, NJ Graber, VM Chinchilli… - Journal of allergy and …, 2010 - Elsevier
BACKGROUND: A subset of children with asthma respond better to leukotriene receptor
antagonists than to inhaled corticosteroids. Information is needed to identify children with
these preferential responses. OBJECTIVE: We sought to determine whether the ratio of
urinary leukotriene E4 (LTE4) to fractional exhaled nitric oxide (FENO) delineates children
with preferential responsiveness to montelukast compared with fluticasone propionate (FP)
therapy. METHODS: Data from 318 children with mild-to-moderate asthma enrolled in 2 …
antagonists than to inhaled corticosteroids. Information is needed to identify children with
these preferential responses. OBJECTIVE: We sought to determine whether the ratio of
urinary leukotriene E4 (LTE4) to fractional exhaled nitric oxide (FENO) delineates children
with preferential responsiveness to montelukast compared with fluticasone propionate (FP)
therapy. METHODS: Data from 318 children with mild-to-moderate asthma enrolled in 2 …