The ARP2/3 complex: an actin nucleator comes of age
The cellular functions of the actin cytoskeleton require precise regulation of both the
initiation of actin polymerization and the organization of the resulting filaments. The actin-
related protein-2/3 (ARP2/3) complex is a central player in this regulation. A decade of study
has begun to shed light on the molecular mechanisms by which this powerful machine
controls the polymerization, organization and recycling of actin-filament networks, both in
vitro and in the living cell.
initiation of actin polymerization and the organization of the resulting filaments. The actin-
related protein-2/3 (ARP2/3) complex is a central player in this regulation. A decade of study
has begun to shed light on the molecular mechanisms by which this powerful machine
controls the polymerization, organization and recycling of actin-filament networks, both in
vitro and in the living cell.
Abstract
The cellular functions of the actin cytoskeleton require precise regulation of both the initiation of actin polymerization and the organization of the resulting filaments. The actin-related protein-2/3 (ARP2/3) complex is a central player in this regulation. A decade of study has begun to shed light on the molecular mechanisms by which this powerful machine controls the polymerization, organization and recycling of actin-filament networks, both in vitro and in the living cell.
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