[HTML][HTML] The p40/ARPC1 subunit of Arp2/3 complex performs multiple essential roles in WASp-regulated actin nucleation
HI Balcer, K Daugherty-Clarke, BL Goode - Journal of biological chemistry, 2010 - ASBMB
The Arp2/3 complex is a conserved seven-subunit actin-nucleating machine activated by
WASp (Wiskott Aldrich syndrome protein). Despite its central importance in a broad range of
cellular processes, many critical aspects of the mechanism of the Arp2/3 complex have yet to
be resolved. In particular, some of the individual subunits in the complex have not been
assigned clear functional roles, including p40/ARPC1. Here, we dissected the structure and
function of Saccharomyces cerevisiae p40/ARPC1, which is encoded by the essential …
WASp (Wiskott Aldrich syndrome protein). Despite its central importance in a broad range of
cellular processes, many critical aspects of the mechanism of the Arp2/3 complex have yet to
be resolved. In particular, some of the individual subunits in the complex have not been
assigned clear functional roles, including p40/ARPC1. Here, we dissected the structure and
function of Saccharomyces cerevisiae p40/ARPC1, which is encoded by the essential …