Cell biology of T cell receptor expression and regulation
A Alcover, B Alarcón, V Di Bartolo - Annual review of …, 2018 - annualreviews.org
A Alcover, B Alarcón, V Di Bartolo
Annual review of immunology, 2018•annualreviews.orgT cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains
that recognize peptide antigens associated with major histocompatibility complex molecules
expressed on the surface of antigen-presenting cells. TCRαβ subunits are associated with
the CD3 complex formed by the γ, δ, ϵ, and ζ subunits, which are invariable and ensure
signal transduction. Here, we review how the expression and function of TCR complexes are …
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains
that recognize peptide antigens associated with major histocompatibility complex molecules
expressed on the surface of antigen-presenting cells. TCRαβ subunits are associated with
the CD3 complex formed by the γ, δ, ϵ, and ζ subunits, which are invariable and ensure
signal transduction. Here, we review how the expression and function of TCR complexes are …
T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains that recognize peptide antigens associated with major histocompatibility complex molecules expressed on the surface of antigen-presenting cells. TCRαβ subunits are associated with the CD3 complex formed by the γ, δ, ϵ, and ζ subunits, which are invariable and ensure signal transduction. Here, we review how the expression and function of TCR complexes are orchestrated by several fine-tuned cellular processes that encompass (a) synthesis of the subunits and their correct assembly and expression at the plasma membrane as a single functional complex, (b) TCR membrane localization and dynamics at the plasma membrane and in endosomal compartments, (c) TCR signal transduction leading to T cell activation, and (d) TCR degradation. These processes balance each other to ensure efficient T cell responses to a variety of antigenic stimuli while preventing autoimmunity.
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