Earlier Expression of the Transcription Factor Hfh–11B Diminishes Induction of P21Cip1/Waf1 Levels and Accelerates Mouse Hepatocyte Entry Into S–Phase …
X Wang, NJ Hung, RH Costa - Hepatology, 2001 - journals.lww.com
Partial hepatectomy (PH) or toxic liver injury induces the proliferation of terminally
differentiated hepatic cells to regenerate the original size of the adult liver. Previous PH liver
regeneration studies showed that premature transgenic expression of the Forkhead Box
M1b (FoxM1b, HFH–11B) transcription factor accelerated hepatocyte entry into DNA
replication (S–phase). In this study, we used carbon tetrachloride (CCl 4) liver injury to
induce a different type of mouse liver regeneration and show that premature hepatic HFH …
differentiated hepatic cells to regenerate the original size of the adult liver. Previous PH liver
regeneration studies showed that premature transgenic expression of the Forkhead Box
M1b (FoxM1b, HFH–11B) transcription factor accelerated hepatocyte entry into DNA
replication (S–phase). In this study, we used carbon tetrachloride (CCl 4) liver injury to
induce a different type of mouse liver regeneration and show that premature hepatic HFH …