Enhancer of zeste homolog 2 (EZH2) regulates stem cells renewal, maintenance, and
differentiation into different cell lineages including neuron. Changes in intracellular Ca 2+
concentration play a critical role in the differentiation of neurons. However, whether EZH2
modulates intracellular Ca 2+ signaling in regulating neuronal differentiation from human
mesenchymal stem cells (hMSCs) still remains unclear. When hMSCs were treated with a
Ca 2+ chelator or a PLC inhibitor to block IP 3-mediated Ca 2+ signaling, neuronal …