[HTML][HTML] A proteomics and transcriptomics approach to identify leukemic stem cell (LSC) markers
F Bonardi, F Fusetti, P Deelen, D van Gosliga… - Molecular & Cellular …, 2013 - ASBMB
Interactions between hematopoietic stem cells and their niche are mediated by proteins
within the plasma membrane (PM) and changes in these interactions might alter
hematopoietic stem cell fate and ultimately result in acute myeloid leukemia (AML). Here,
using nano-LC/MS/MS, we set out to analyze the PM profile of two leukemia patient
samples. We identified 867 and 610 unique CD34+ PM (-associated) proteins in these AML
samples respectively, including previously described proteins such as CD47, CD44, CD135 …
within the plasma membrane (PM) and changes in these interactions might alter
hematopoietic stem cell fate and ultimately result in acute myeloid leukemia (AML). Here,
using nano-LC/MS/MS, we set out to analyze the PM profile of two leukemia patient
samples. We identified 867 and 610 unique CD34+ PM (-associated) proteins in these AML
samples respectively, including previously described proteins such as CD47, CD44, CD135 …