[HTML][HTML] Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production
C Liu, S Hutchens, T Jursa, W Shawlot… - Journal of Biological …, 2017 - ASBMB
SLC30A10 and SLC39A14 are manganese efflux and influx transporters, respectively. Loss-
of-function mutations in genes encoding either transporter induce hereditary manganese
toxicity. Patients have elevated manganese in the blood and brain and develop
neurotoxicity. Liver manganese is increased in patients lacking SLC30A10 but not
SLC39A14. These organ-specific changes in manganese were recently recapitulated in
knockout mice. Surprisingly, Slc30a10 knockouts also had elevated thyroid manganese and …
of-function mutations in genes encoding either transporter induce hereditary manganese
toxicity. Patients have elevated manganese in the blood and brain and develop
neurotoxicity. Liver manganese is increased in patients lacking SLC30A10 but not
SLC39A14. These organ-specific changes in manganese were recently recapitulated in
knockout mice. Surprisingly, Slc30a10 knockouts also had elevated thyroid manganese and …