[HTML][HTML] The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu
S Schweiger, S Dorn, M Fuchs, A Köhler… - Journal of Biological …, 2014 - ASBMB
SHH (Sonic Hedgehog)-GLI signaling plays an important role during embryogenesis and in
tumorigenesis. The survival and growth of several types of cancer depend on autonomously
activated SHH-GLI signaling. A protein complex containing the ubiquitin ligase MID1 and
protein phosphatase 2A regulates the nuclear localization and transcriptional activity of
GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously
activated SHH signaling. However, the exact molecular mechanisms that mediate the …
tumorigenesis. The survival and growth of several types of cancer depend on autonomously
activated SHH-GLI signaling. A protein complex containing the ubiquitin ligase MID1 and
protein phosphatase 2A regulates the nuclear localization and transcriptional activity of
GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously
activated SHH signaling. However, the exact molecular mechanisms that mediate the …