Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis
J Hu, A Geyer, S Dziumbla, K Awwad, DC Zeldin… - Prostaglandins & Other …, 2017 - Elsevier
Polyunsaturated fatty acids (PUFA) and their cytochrome P450 (CYP450) metabolites have
been linked to angiogenesis and vessel homeostasis. However, the role of individual CYP
isoforms and their endogenous metabolites in those processes are not clear. Here, we
focused on the role of Cyp2c44 in postnatal retinal angiogenesis and report that Cyp2c44 is
highly expressed in Müller glial cells in the retina. The constitutive as well as inducible
postnatal genetic deletion of Cyp2c44 resulted in an increased vessel network density …
been linked to angiogenesis and vessel homeostasis. However, the role of individual CYP
isoforms and their endogenous metabolites in those processes are not clear. Here, we
focused on the role of Cyp2c44 in postnatal retinal angiogenesis and report that Cyp2c44 is
highly expressed in Müller glial cells in the retina. The constitutive as well as inducible
postnatal genetic deletion of Cyp2c44 resulted in an increased vessel network density …