[HTML][HTML] Transmigrated neutrophils in the intestinal lumen engage ICAM-1 to regulate the epithelial barrier and neutrophil recruitment

R Sumagin, AZ Robin, A Nusrat, CA Parkos - Mucosal immunology, 2014 - Elsevier
Neutrophil (PMN) transepithelial migration (TEM) and accumulation in luminal spaces is a
hallmark of mucosal inflammation. TEM has been extensively modeled; however, the
functional consequences and molecular basis of PMN interactions with luminal epithelial
ligands are not clear. Here we report that cytokine-induced expression of a PMN ligand,
intercellular adhesion molecule-1 (ICAM-1), exclusively on the luminal (apical) membrane of
the intestinal epithelium results in accumulation and enhanced motility of transmigrated …