[HTML][HTML] Alternative splicing factor/splicing factor 2 regulates the expression of the ζ subunit of the human T cell receptor-associated CD3 complex
VR Moulton, GC Tsokos - Journal of biological chemistry, 2010 - ASBMB
T cells from patients with systemic lupus erythematosus express decreased levels of the T
cell receptor-associated CD3 ζ chain, a feature directly linked to their aberrant function. The
decrease in CD3ζ protein expression is in part due to decreased levels of functional wild
type isoform of the 3′-untranslated region (UTR) of CD3ζ mRNA with concomitant
increased levels of an unstable alternatively spliced isoform. In order to identify factors
involved in the post-transcriptional regulation of CD3ζ, we performed mass spectrometric …
cell receptor-associated CD3 ζ chain, a feature directly linked to their aberrant function. The
decrease in CD3ζ protein expression is in part due to decreased levels of functional wild
type isoform of the 3′-untranslated region (UTR) of CD3ζ mRNA with concomitant
increased levels of an unstable alternatively spliced isoform. In order to identify factors
involved in the post-transcriptional regulation of CD3ζ, we performed mass spectrometric …