[HTML][HTML] Transcription factor ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21 waf1 transcription in human cells
L Bai, JL Merchant - Journal of Biological Chemistry, 2000 - ASBMB
Inducible p53-independent regulation of the cyclin-dependent kinase inhibitor p21 waf1
transcription is mediated through proximal GC-rich sites. Prior studies have shown that Sp1,
Sp3, and the histone acetylase co-activator p300 are components of the complexes binding
to these sites. Although Sp1 and Sp3 collaborate with p300, a direct interaction between
Sp1 and p300 does not occur. This study sought to determine whether ZBP-89 rather than
Sp1 is the direct target of p300 during butyrate induction of p21 waf1. ZBP-89 (BFCOL1 …
transcription is mediated through proximal GC-rich sites. Prior studies have shown that Sp1,
Sp3, and the histone acetylase co-activator p300 are components of the complexes binding
to these sites. Although Sp1 and Sp3 collaborate with p300, a direct interaction between
Sp1 and p300 does not occur. This study sought to determine whether ZBP-89 rather than
Sp1 is the direct target of p300 during butyrate induction of p21 waf1. ZBP-89 (BFCOL1 …