Beneficial effects of myo-inositol oxygenase deficiency in cisplatin-induced AKI
Overexpression of the proximal tubular enzyme myo-inositol oxygenase (MIOX) induces
oxidant stress in vitro. However, the relevance of MIOX to tubular pathobiology remains
enigmatic. To investigate the role of MIOX in cisplatin-induced tubular AKI, we generated
conditional MIOX-overexpressing transgenic (MIOX-TG) mice and MIOX-knockout (MIOX−/−)
mice with tubule-specific MIOX overexpression or knockout, respectively. Compared with
cisplatin-treated wild-type (WT) mice, cisplatin-treated MIOX-TG mice had even greater …
oxidant stress in vitro. However, the relevance of MIOX to tubular pathobiology remains
enigmatic. To investigate the role of MIOX in cisplatin-induced tubular AKI, we generated
conditional MIOX-overexpressing transgenic (MIOX-TG) mice and MIOX-knockout (MIOX−/−)
mice with tubule-specific MIOX overexpression or knockout, respectively. Compared with
cisplatin-treated wild-type (WT) mice, cisplatin-treated MIOX-TG mice had even greater …