Regulation of oxidative stress and redox systems has important roles in carcinogenesis and
cancer progression, and for this reason has attracted much attention as a new area of
cancer therapeutic targets. Glutathione peroxidase 4 (GPX4), an antioxidant enzyme, has
biological important functions such as signaling cell death by suppressing peroxidation of
membrane phospholipids. However, few studies exist on the expression and clinical
relevance of GPX4 in malignant lymphomas such as diffuse large B-cell lymphoma. In this …