Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells
K Totsuka, T Ueta, T Uchida, MF Roggia… - Experimental eye …, 2019 - Elsevier
The dysfunction and cell death of retinal pigment epithelial (RPE) cells are hallmarks of late-
stage dry (atrophic) age-related macular degeneration (AMD), for which no effective therapy
has yet been developed. Previous studies have indicated that iron accumulation is a source
of excess free radical production in RPE, and age-dependent iron accumulation in RPE is
accelerated in patients with dry AMD. Although the pathogenic role of oxidative stress in
RPE in the development of dry AMD is widely accepted, the mechanisms of oxidative stress …
stage dry (atrophic) age-related macular degeneration (AMD), for which no effective therapy
has yet been developed. Previous studies have indicated that iron accumulation is a source
of excess free radical production in RPE, and age-dependent iron accumulation in RPE is
accelerated in patients with dry AMD. Although the pathogenic role of oxidative stress in
RPE in the development of dry AMD is widely accepted, the mechanisms of oxidative stress …