Airway epithelial cells from asthmatic children differentially express proremodeling factors
JM Lopez-Guisa, C Powers, D File, E Cochrane… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: The airway epithelium can express factors that drive subepithelial airway
remodeling. TGF-β2, vascular epithelial growth factor (VEGF), a disintegrin and
metalloprotease 33 (ADAM33), and periostin are hypothesized to be involved in
subepithelial remodeling and are overexpressed in adult asthmatic airways. Epidemiologic
data suggest that lung function deficits in asthmatic patients are acquired in childhood.
OBJECTIVES: We sought to determine whether airway epithelial cells (AECs) from asthmatic …
remodeling. TGF-β2, vascular epithelial growth factor (VEGF), a disintegrin and
metalloprotease 33 (ADAM33), and periostin are hypothesized to be involved in
subepithelial remodeling and are overexpressed in adult asthmatic airways. Epidemiologic
data suggest that lung function deficits in asthmatic patients are acquired in childhood.
OBJECTIVES: We sought to determine whether airway epithelial cells (AECs) from asthmatic …