Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation …
AS Kirshenbaum, C Akin, Y Wu, M Rottem, JP Goff… - Leukemia research, 2003 - Elsevier
Two novel stem cell factor (SCF) dependent human mast cell lines, designated LAD 1 and 2,
were established from bone marrow aspirates from a patient with mast cell
sarcoma/leukemia. LAD 1 and 2 cells have the ultrastructural features of human mast cells,
and express FcεRI, CD4, 9, 13, 14, 22, 31, 32, 45, 64, 71, 103, 117, 132, CXCR4 (CD184),
CCR5 (CD195); and intracytoplasmic histamine, tryptase and chymase. LAD 1 and 2 do not
exhibit activating mutations at codon 816 of c-kit. Both LAD 1 and 2 release β …
were established from bone marrow aspirates from a patient with mast cell
sarcoma/leukemia. LAD 1 and 2 cells have the ultrastructural features of human mast cells,
and express FcεRI, CD4, 9, 13, 14, 22, 31, 32, 45, 64, 71, 103, 117, 132, CXCR4 (CD184),
CCR5 (CD195); and intracytoplasmic histamine, tryptase and chymase. LAD 1 and 2 do not
exhibit activating mutations at codon 816 of c-kit. Both LAD 1 and 2 release β …