[HTML][HTML] Accelerated development of pulmonary fibrosis via Cu, Zn-superoxide dismutase-induced alternative activation of macrophages
C He, AJ Ryan, S Murthy, AB Carter - Journal of Biological Chemistry, 2013 - ASBMB
Macrophages not only initiate and accentuate inflammation after tissue injury, but they are
also involved in resolution and repair. This difference in macrophage activity is the result of a
differentiation process to either M1 or M2 phenotypes. M1 macrophages are pro-
inflammatory and have microbicidal and tumoricidal activity, whereas the M2 macrophages
are involved in tumor progression and tissue remodeling and can be profibrotic in certain
conditions. Because mitochondrial Cu, Zn-superoxide dismutase (Cu, Zn-SOD)-mediated H …
also involved in resolution and repair. This difference in macrophage activity is the result of a
differentiation process to either M1 or M2 phenotypes. M1 macrophages are pro-
inflammatory and have microbicidal and tumoricidal activity, whereas the M2 macrophages
are involved in tumor progression and tissue remodeling and can be profibrotic in certain
conditions. Because mitochondrial Cu, Zn-superoxide dismutase (Cu, Zn-SOD)-mediated H …