[HTML][HTML] Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly
MM Hussain, J Shi, P Dreizen - Journal of lipid research, 2003 - ASBMB
Apolipoprotein B (ap1111190) and microsomal triglyceride transfer protein (MTP) are
necessary for lipoprotein assembly. ApoB consists of five structural domains, βα 1-β 1-α 2-β
2-α 3. We propose that MTP contains three structural motifs (N-terminal β-barrel, central α-
helix, and C-terminal lipid cavity) and three functional domains (lipid transfer, membrane
associating, and apoB binding). MTP's lipid transfer activity is required for the assembly of
lipoproteins. This activity renders nascent apoB secretion-competent and may be involved in …
necessary for lipoprotein assembly. ApoB consists of five structural domains, βα 1-β 1-α 2-β
2-α 3. We propose that MTP contains three structural motifs (N-terminal β-barrel, central α-
helix, and C-terminal lipid cavity) and three functional domains (lipid transfer, membrane
associating, and apoB binding). MTP's lipid transfer activity is required for the assembly of
lipoproteins. This activity renders nascent apoB secretion-competent and may be involved in …