[HTML][HTML] DNA damage-induced ATM-and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH …
MG Kemp - Journal of Biological Chemistry, 2017 - ASBMB
The role of the DNA damage response protein kinase ataxia telangiectasia-mutated (ATM)-
and Rad-3-related (ATR) in the cellular response to DNA damage during the replicative
phase of the cell cycle has been extensively studied. However, little is known about ATR
kinase function in cells that are not actively replicating DNA and that constitute most cells in
the human body. Using small-molecule inhibitors of ATR kinase and overexpression of a
kinase-inactive form of the enzyme, I show here that ATR promotes cell death in non …
and Rad-3-related (ATR) in the cellular response to DNA damage during the replicative
phase of the cell cycle has been extensively studied. However, little is known about ATR
kinase function in cells that are not actively replicating DNA and that constitute most cells in
the human body. Using small-molecule inhibitors of ATR kinase and overexpression of a
kinase-inactive form of the enzyme, I show here that ATR promotes cell death in non …